Adventures in Slime and Space

One of Egon's contraptions has a bad effect on Slimer, making millions of little versions of the green ghost. Worse, when they try to fix the problem, Slimer turns evil and starts causing trouble across the entire city, which ends up slimed to great excess. The show itself is infamous for its numerous in-jokes such as Pac-Man, 2001: A Space Odyssey, King Kong, The Three Stooges, even Star Trek and Adventures in Time and Space.